Severe Neutropenia Definition Clozapine. Management of 2 patients with severe neutropenia was as follows. Severe neutropenia can lead to serious infection and death. Clozapine can cause severe neutropenia which can lead to serious infections and death. Clozapine is available only from a certified pharmacy under a special program.
Due to the history of unsatisfactory response to traditional antipsychotics clozapine treatment was continued despite white blood cell WBC decline. Severity of neutropenia was stratified as mild 10001500 per µL mod-. Clozapine affects your immune system. Severe neutropenia can be life-threatening. Clozapine can cause severe neutropenia. And prophylactic antibiotic therapy.
Leucopenia a reduction in the number of white blood cells WBC without neutropenia may also occur.
Clozapine can cause severe neutropenia. Patients with a lower ANC. Clozapine carries a black box warning for drug-induced agranulocytosis lowered white blood cell count. Due to the history of unsatisfactory response to traditional antipsychotics clozapine treatment was continued despite white blood cell WBC decline. However delayed cases have been reported. Severe neutropenia is defined as ANC less than 500μL Severe neutropenia replaces the previous terms severe leukopenia severe.